From Manual Interpretation to Measurable Metrics: Kappa Index Integration in Multiple Sclerosis Diagnosis, Alison Whitelegg
Clinical utility of the kappa index in assessing intrathecal free light chain synthesis and its role alongside oligoclonal bands in MS diagnostics.
(CH)50 shades of grey: challenges interpreting complement results, Adrian Heaps
Practical challenges in complement testing, including functional assays, discrepancies, and clinical correlation.
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Alison Whitelegg
Alison Whitelegg is a Consultant clinical scientist in Immunology at University Hospital Southampton and the Immunology clinical lead at Portsmouth University Hospitals NHS Trust. She leads laboratory immunology services across both organisations, overseeing diagnostic pathways, service development, and the delivery of high-quality patient care.
Recently, Alison has been leading the practical rollout of the CSF kappa light chain index test for multiple sclerosis across the South 6 Pathology Network, helping bring this important diagnostic tool into routine clinical use.
Alison Whitelegg also plays a national leadership role as Chair of the Immunology Professional Committee, supporting the development and standards of Immunology Clinical Scientists across the UK. She has worked in the NHS for 20 years and remains committed to training and mentoring the next generation of clinical scientists.
Her academic background includes a PhD from the Pirbright Institute and postdoctoral research at the Anthony Nolan Research Institute, with a focus on T-cell and vaccine-specific immune responses.
